Stockholms kommun, Stockholm County, Sweden
Member Since 2023
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EnginZyme AB

About my Start-up

EnginZyme is solving one of the fundamental challenges of our time – how to produce chemicals, foods, materials and other products that modern society relies on, in a truly sustainable way. This is done by making it easier and more cost efficient to use enzymes. EnginZyme’s cell-free processes can be retrofitted in equipment already established in the industry, avoiding high CapEx. We have a portfolio of patents granted globally for our basic EziG technology, covering general enzyme immobilisations and their use in production processes. Our proprietary immobilisation technology eliminates several common issues with enzyme immobilisation and is broadly applicable, demonstrated by successful immobilisation and utilisation of all enzyme classes. By utilising our ground-breaking cell-free biomanufacturing technology we can replace traditional fossil-based and energy–intensive chemical production with a biological alternative that is both economical and sustainable.

Why your idea is a “winner"?:

Our direct competitors are companies using synthetic biotechnology to develop manufacturing processes, such as Gingko, Genomatica, Solugen, etc.

- We differentiate from companies that rely on cell based processes as we are using enzymes, which enables faster, simpler and more robust process development. Cell based technologies are more complex and difficult to scale-up due to the sensitivity of living organisms (toxicity, low productivity and cell debris leading to costly purification, inhomogeneous, large and complex reactors,...).

- Companies using enzymes in their development need to circumvent some challenges that EnginZyme is solving. Our key strength is the utilisation of immobilised enzymes to develop high performance biocatalysts with long lifetime and high productivity. We are able to develop novel and bespoke solutions as our capabilities range from enzyme engineering & development, biocatalyst development to process development and piloting of manufacturing processes.

What is your current or intended business/revenue model?:

We generate revenues through customer driven projects and internal projects. We develop new manufacturing processes that we can commercialize as:
1- catalyst supply to manufacturing partner or customer,
2- process license,
3- production & marketing of chemicals (under a JV with partner, own production unit or contract manufacturing)

Do you have any Patent or IP registered (related to the solution that you are looking for an investment)?:

We have a portfolio of patents granted globally for our basic EziG technology, covering general enzyme immobilisations and their use in production processes. Our proprietary immobilisation technology eliminates several common issues with enzyme immobilisation and is broadly applicable, demonstrated by successful immobilisation and utilisation of all enzyme classes.

Has your technology already been implemented in any field/sector?:

We are currently developing several solutions across market verticals:
- Edible oil processing: we are creating a biocatalyst outperforming incumbent one, currently scaling up and ready for industrial use in Q3/2024 with our codevelopment customer
- Enzymatic processes to improve existing sweeteners production or develop new sweeteners: we piloted the process and we are launching a dedicated spinout to obtain food approvals and commercial launch of kojibiose (prebiotic low calorie sweetener)
- We are developing a process to produce high value intermediates for mRNA vaccines
- We developed a process and produced samples for alpha-arbutin, a cosmetic ingredient. We are looking for off-takers and process licensees

Which market and customer need(s)/problem(s) is (are) your products(s)/service(s) going to solve?:

Many green chemistry companies have biomimetic processes — imitating what nature does. In nature enzymes are the key catalysts that allow cells to create chemicals necessary for life. But using living cells to manufacture chemicals industrially can be complex and requires a highly conditioned environment known as a bioreactor. EnginZyme enables cell-free processes in equipment already established in the industry, avoiding high CapEx. Additionally, EnginZyme’s tailored, stable, solid biocatalysts can be used both as a standard heterogeneous catalyst in batch and in continuous processes, therefore enabling more productive and efficient manufacturing. Furthermore, EnginZyme does not only focus on the performance of the catalyst. Instead we evaluate and design a complete process solution from raw materials to products. By designing with the end commercial solution in mind, the scale-up is faster and risks are mitigated. In every new project we perform techno economic assessments, analysing the economic performance of proposed industrial process or product to ensure we met set cost targets.
We are developing processes & products in several markets as we have a versatile technology (food, nutraceuticals, cosmetics, chemical intermediates, APIs, etc)

Trl
TRL 5 – technology validated in relevant environment (industrially relevant environment in the case of key enabling technologies)
Candidate Overview

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